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FREQUENTLY ASKED QUESTIONS
- What is Serzone antidepressant drug?
- How does Serzone antidepressant drug work?
- What is Serzone antidepressant drug liver
damage?
- What are some other Serzone antidepressant
drug side effects?
- What did a pre-marketing study show about Serzone
antidepressant drug?
- Why did the FDA issue a Black Box warning
be put on the label of Serzone antidepressant drug?
- What are possible adverse liver side effects
caused by the use of Serzone antidepressant drug?
- What are some signs of Serzone antidepressant
drug liver damage?
- What legal rights do I have regarding Serzone
antidepressant drug?
- How do I find a qualified Serzone lawyer?
1. What is Serzone antidepressant drug?
Manufactured by Bristol-Myers Squibb Company, Serzone antidepressant
drug, or nefazodone hydrochloride, has been used by more than 7
million Americans. Serzone antidepressant drug has been prescribed
for treatment of depression with or without anxiety or sleeplessness.
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2. How does Serzone antidepressant drug work?
The antidepressant action of Serzone (nefazodone) is thought to
be dependent on its ability to block postsynaptic serotonin type-2
receptors and inhibit presynaptic serotonin reuptake. Serzone antidepressant
drug also blocks norepinephrine reuptake. Serzone antidepressant
drug does not have a chemical structure similar to the SSRIs, tricyclic
antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine.
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3. What is Serzone antidepressant drug
liver damage?
Serzone antidepressant drug has been associated to serious cases
of liver failure resulting in transplant and/or death. The time
to liver injury for the reported liver failure cases resulting in
death or transplant generally ranged from two weeks to six months
on Serzone therapy. Reports of Serzone liver damage in patients
using the antidepressant drug has caused the FDA to order two label
changes to strengthen the warning for the adverse effects that have
resulted from the drug's use.
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4. What are some other side effect of
Serzone antidepressant drug?
Common side effects of Serzone antidepressant drug include, headaches,
constipation, dry mouth, drowsiness, insomnia, nausea, vision problems,
agitation, dizziness, fatigue, confusion, hypotension, rash or hives,
seizures, and lightheadedness.
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5. What did a pre-marketing study show about
Serzone antidepressant drug?
In a study performed prior to Serzone's marketing 16% of the patients
discontinued their use of the antidepressant drug due to adverse
Serzone side effects they experienced.
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6. Why did the FDA issue a Black Box warning
be put on the label of Serzone antidepressant drug?
The FDA ordered that Bristol-Myers include the strongest type of
warning possible, a Black Box warning, on the label of Serzone antidepressant
drug in December 2001 because of the Serzone liver damage cases.
The black box name is referring to the thick black outline that
surrounds the warning on the label. The warnings included the information
that transplant and/or death can occur due to the liver failure
instances. January 2002, the label information for Serzone antidepressant
drug was revised once again strengthening the warnings, contraindications,
and precautions sections as Serzone liver failure continued to be
reported.
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7. What are possible adverse liver side
effects caused by the use of Serzone antidepressant drug?
Liver effects range from asymptomatic reversible increases in serum
transaminase to cases of liver failure resulting in transplant or
death.
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8. What are some signs of Serzone antidepressant
drug liver damage?
Signs of liver dysfunction include (but are not limited to):
- Yellowing of the skin or the whites of the
eyes (jaundice)
- Unusually dark urine
- Nausea
- Abdominal pain
- Loss of appetite that lasts several days or longer
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9. What legal rights do I have regarding
Serzone antidepressant drug?
If you have taken Serzone antidepressant drug, you are at risk for
potentially fatal Serzone side effects, including cases of liver
failure. Although the FDA ordered that Serzone manufacturer strengthen
their label on two separate occasions, this FDA practice has been
highly criticized for its ineffectiveness. Doctors have even admitted
never looking at labels that have been changed after the FDA has
ordered strengthened label indications. Critics wonder what type
of impact a leaflet warning of possible death or serious injury
can have in fine print. To learn about your legal rights please
contact a Serzone Lawyer.
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10. How do I find a qualified Serzone lawyer?
Our experienced team of lawyers has a proven track record of successfully
defending individuals unnecessarily injured. Serzone has been directly
linked to cases of liver failure that have resulted in transplant
and/or death. Please contact us to learn more about what compensation
you may be eligible for.
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